Future target-based drug discovery for tuberculosis?
نویسندگان
چکیده
منابع مشابه
Mycobacterium tuberculosis DNA gyrase as a target for drug discovery.
Bacterial DNA gyrase is an important target of antibacterial agents, including fluoroquinolones. In most bacterial species, fluoroquinolones inhibit DNA gyrase and topoisomerase IV and cause bacterial cell-death. Other naturally occurring bacterial DNA gyrase inhibitors, such as novobiocin, are also known to be effective as antibacterial agents. DNA gyrase is an ATP-dependent enzyme that acts b...
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Increasing bacterial drug resistance and hard-to-eradicate opportunistic infections have created a need for new antibiotics. Sequencing of microbial genomes has yielded many new potential targets for antibacterial drug discovery. However, little is known about the biochemical activities of many of these targets, making it difficult to develop HTS assays for them. Peptides isolated by phage disp...
متن کاملNovel targets for tuberculosis drug discovery.
Since the determination of the Mycobacterium tuberculosis genome sequence, various groups have used the genomic information to identify and validate targets as the basis for the development of new anti-tuberculosis agents. Validation might include many components: demonstration of the biochemical activity of the enzyme, determination of its crystal structure in complex with an inhibitor or a su...
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ژورنال
عنوان ژورنال: Tuberculosis
سال: 2014
ISSN: 1472-9792
DOI: 10.1016/j.tube.2014.10.003